Accession Number:

ADA568099

Title:

Model-Based, Noninvasive Monitoring of Intracranial Pressure

Descriptive Note:

Annual rept. 16 Sep 2011-15 Sep 2012

Corporate Author:

MASSACHUSETTS INST OF TECH CAMBRIDGE

Personal Author(s):

Report Date:

2012-10-01

Pagination or Media Count:

18.0

Abstract:

The project aims i to further develop and validate a novel model-based approach to noninvasive, calibration free determination of intracranial pressure ICP from quantities that are routinely measured in clinical settings, and ii to initiate the creation of a publicly available reference database of physiological signals collected from brain injury patients. Our noninvasive ICP nICP estimate requires simultaneous measurement of the waveforms of arterial blood pressure ABP, obtained via radial artery catheter or finger cuff, and of cerebral blood flow velocity CBFV at a major cerebral artery, measured by transcranial Doppler TCD. The target population for our initial database comprises subarachnoid hemorrhage patients in neuro-intensive care at our partner hospital, for whom ICP, ABP and CBFV are currently measured as the clinical standard of care. Our major accomplishments so far on this project include assembling a component-based system to support data collection and processing in the intensive care setting converting our earlier batch-mode nICP estimation algorithms to run continuously and in real time developing the associated software and user interfaces arranging for the data-collection modalities to satisfy an existing IRB that allows the collected data to be transferred to the publicly accessible MIMIC II database and familiarizing the hospital staff with the equipment and procedures. We have also continued to work on developing signal-quality metrics, and have refinements and extensions of the underlying estimation algorithms.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE