Abnormal Vestibulo-Ocular Reflexesin Autism: A Potential Endophenotype
Annual rept. 15 May 2011-14 May 2012
FLORIDA UNIV GAINESVILLE
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The overarching objective of this study is to characterize abnormalities of vestibulo-ocular reflexes VOR in Autism Spectrum Disorder ASD. Specific aim 1 Characterize horizontal VOR post-rotary nystagmus without optokinetic feedback using a velocity step test. We hypothesize that in ASD vertical eye movement intrusions during horizontal nystagmus will occur more frequently than normal, will be time-locked to horizontal nystagmus, and will differ from voluntary saccades. Specific aim 2 Characterize horizontal VOR without optokinetic feedback using sinusoidal oscillation tests. We hypothesize that gain and phase lag of horizontal VOR will differ in children with ASD compared to controls. Specific aim 3 Characterize in ASD vertical VOR and torsional VOR, both without optokinetic feedback. The present report covers the second year following award initiation. Complete research data have been obtained from one child with ASD and 18 typically developing children.
- Anatomy and Physiology
- Medicine and Medical Research