Characterization of the Pathological and Biochemical Markers that Correlate to the Clinical Features of Autism
Annual rept. 22 Sep 2011-21 Sep 2012
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC STATEN ISLAND NY
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Brain tissue is highly heterogeneous with different functions localized in specific areas. Our results suggest that there is increased oxidative damage coupled with reduced glutathione antioxidant capacity in the selective regions of the brain in the subjects with autism. These changes in autism were specific to the frontal cortex, temporal cortex and cerebellum, while parietal and occipital cortices were not affected. Free radicals and energy ATP are generated by the mitochondrial in the cell with the help of mitochondrial electron transport chain ETC complexes. We have also reported brain region-specific deficit in mitochondrial ETC complexes in children.with autism. Autism spectrum disorders ASDs are complex neurodevelopmental disorders. The complexity of ASDs is further increased because some affected individuals fall in the sub-group of regressive autism. We report here that individuals with regressive autism have decreased activities of protein kinases, i.e. protein kinase A PKA and protein kinase C PKC in the frontal cortex of the brain. Such changes were not observed in individuals with non-regressive autism. These results suggest that abnormal cellular signaling in the frontal lobe of the brain may be associated with regression in autism.
- Medicine and Medical Research