Accession Number:

ADA568023

Title:

Non-thermal High-intensity Focused Ultrasound for Breast Cancer Therapy

Descriptive Note:

Annual rept. 1 Jul 2011-30 Jun 2012

Corporate Author:

FOX CHASE CANCER CENTER PHILADELPHIA PA

Personal Author(s):

Report Date:

2012-07-01

Pagination or Media Count:

17.0

Abstract:

Several in vitro studies have demonstrated the non-thermal 42 deg C cell killing effect of HIFU, which resembles high linear energy transfer LET radiation cell damage that is not affected by the local biochemical environment and shows less radiation resistance. However, there have been no in vivo animal studies performed on non-thermal HIFU to demonstrate its therapeutic potential. This project aims to demonstrate the therapeutic potential of non-thermal HIFU in vivo using an animal model by comparing it with well established treatment modalities such as radiation therapy. This project has two aims 1 to determine if non-thermal HIFU can cause significant tumor growth delays in vivo as compared to radiation therapy using an animal breast cancer model, and 2 to determine potential normal tissue toxicities, if any, associated with non-thermal HIFU treatment for breast cancer. Extensive phantom studies have been completed to determine suitable ultrasound parameters for the in vivo animal experiments. However, the tasks planned for the animal studies were not completed due to the delayed approval of the animal protocol. A no-cost extension has been approved to complete the remaining tasks by the end of June 2013.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE