Accession Number:

ADA567829

Title:

Alcohol Intoxication Impact on Outcome from Traumatic Injury

Descriptive Note:

Final rept. 3 Apr 2008-2 Apr 2011

Corporate Author:

LOUISIANA STATE UNIV NEW ORLEANS

Personal Author(s):

Report Date:

2011-05-01

Pagination or Media Count:

29.0

Abstract:

Acute alcohol intoxication AAI impairs the hemodynamic counteregulatory response to trauma and hemorrhagic shock HS, blunts the pressor response to fluid resuscitation FR, suppresses the HS induced neuroendocrine response, impairs pro-inflammatory cytokine expression and increases mortality from infection during recovery. Studies conducted during this funding period examined a whether the attenuated neuroendocrine response, particularly reduced sympathetic nervous system SNS activation, is the principal mechanism responsible for the hemodynamic instability seen in AAI HS and b what the impact of AAI was on the integrity of host defense mechanisms during the immediate and delayed recovery from HS. We determined whether SNS activation can be restored by central intracerebroventricular ICV neostigmine administration and whether this in turn is capable of improving the hemodynamic counteregulatory response to HS in AAI. Our results show that ICV neostigmine stimulates SNS activation and improves the recovery of blood pressure following hemorrhagic shock. Furthermore, our results indicate that this in part mediated by arginine vasopressin. Interestingly while the presser response to phenylephrine in vitro appears to be blunted by alcohol, the in vivo response to a presser with a different mechanism of action appears to be preserved.

Subject Categories:

  • Psychology
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE