The Use of Drugs to Reduce Hearing Loss Following Acute Acoustic Trama
Annual rept. 25 Jun 2011-24 Jun 2012
STATE UNIV OF NEW YORK COLL AT PLATTSBURGH
Pagination or Media Count:
Following a 108 dB SPL, 4 kHz noise exposure for 6 hours, animals were treated in a rescue paradim with N-Acetyl l-cysteine, Ebselen, D-Methionine, Acetyl L-Carnitine or the Src protein tyrosine kinase inhibitor, KX1-004 and compared to untreated control subjects. Hearing loss, distortion product emissions and cochlear histology data were obtained in each animal. Statistical analyses indicated that there were no significant differences between the control and treated groups. The above five drugs were also applied in a rescue paradigm to groups of animals exposed to 10, 158 dB peak SPL blast waves. Data collection from two drug L-NAC and D-MET treated groups and one control group N20group is complete. Three groups N20group have been exposed and treated with ALCAR, Ebselen or Src Inh. Data collection and analysis on these groups is not complete. Variability in the response of animals to the blast exposures is a complicating factor. As a result of the variability in the blast wave control group, data on a second group N20 of noise only control subjects is being collected.