Accession Number:

ADA566979

Title:

Genetic Modifiers of Ovarian Cancer

Descriptive Note:

Annual rept. 15 May 2011-14 May 2012

Corporate Author:

MAYO CLINIC ROCHESTER MN

Personal Author(s):

• Couch, Fergus J.

Report Date:

2012-06-01

Pagination or Media Count:

11.0

Abstract:

Individuals with germline mutations in BRCA1 have an elevated but incomplete risk of developing ovarian cancer suggesting the presence of genetic modifiers of ovarian cancer in this population. A genome wide association study GWAS for ovarian cancer in BRCA1 mutation carriers was initiated in an effort to identify common genetic variants that modify ovarian cancer risk. Discovery and validation studies have identified several novel modifiers of ovarian cancer risk for BRCA1 mutation carriers that can be used for individualized ovarian cancer risk assessment.

Descriptors:

• *GENETICS
• *OVARIAN CANCER
• DISEASE VECTORS
• GENETIC ENGINEERING
• GENOME
• RISK

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE