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Genetic Modifiers of Ovarian Cancer
Annual rept. 15 May 2011-14 May 2012
MAYO CLINIC ROCHESTER MN
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Individuals with germline mutations in BRCA1 have an elevated but incomplete risk of developing ovarian cancer suggesting the presence of genetic modifiers of ovarian cancer in this population. A genome wide association study GWAS for ovarian cancer in BRCA1 mutation carriers was initiated in an effort to identify common genetic variants that modify ovarian cancer risk. Discovery and validation studies have identified several novel modifiers of ovarian cancer risk for BRCA1 mutation carriers that can be used for individualized ovarian cancer risk assessment.
APPROVED FOR PUBLIC RELEASE