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Lower Prediagnostic Serum 25-Hydroxyvitamin D Concentration Is Associated With Higher Risk of Insulin-requiring Diabetes: A Nested Case-Control Study
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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Aimshypothesis Low serum 25-hydroxyvitamin D 25 OHD concentration may increase risk of insulinrequiring diabetes. Methods A nested case control study was performed using serum collected during 2002 2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date 2 days, age 3 months, length of service 30 days and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year range 1 month to 10 years. Statistical analysis used matched pairs and conditional logistic regression.
APPROVED FOR PUBLIC RELEASE