Accession Number:

ADA566819

Title:

Redox Regulation in Bone Marrow Failure

Descriptive Note:

Final rept. 1 Apr 2010-31 May 2012

Corporate Author:

THOMAS JEFFERSON UNIV PHILADELPHIA PA

Personal Author(s):

• Pan, Shi

Report Date:

2012-06-01

Pagination or Media Count:

18.0

Abstract:

Bone marrow failure is a group of hematopoietic stem cell disorders that affect one or more lineages of blood cells. Although the causes for bone marrow failure are complicated and not completely understood, oxidative stress has been recognized as a key contributor 1 2 3 4 5 6. Hematopoietic stem cells are highly sensitive to reactive oxygen species ROS 7, 8. Accumulation of ROS activates p38, shortens the life span of hematopoietic stem cells, disrupts the homeostasis of hematopoietic stem cells, and eventually causes bone marrow failure 7, 8 9 10. The key role of p38 in the development of bone marrow failure has also been demonstrated by the finding that treating aplastic anemia patients with a p38 MAPK inhibitor can restore defective hematopoietic activity, suggesting the critical role of p38 in bone marrow failure 11.

Descriptors:

• *BONE MARROW
• ACCUMULATION
• BLOOD CELLS
• DEFECTS(MATERIALS)
• HEMATOPOIETIC CELLS
• INHIBITORS
• LIFE SPAN(BIOLOGY)
• STEM CELLS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE