Accession Number:

ADA566787

Title:

ICBP90 Regulation of DNA Methylation, Histone Ubiquitination, and Tumor Suppressor Gene Expression in Breast Cancer Cells

Descriptive Note:

Annual summary rept. 1 Jul 2011-30 Jun 2012

Corporate Author:

CORNELL UNIV ITHACA NY

Personal Author(s):

• Shook, Molly S.
• Cravens, Elena N.
• Hughes, Erika J.
• Coonrod, Scott A.
• Richards, Eric J.

Report Date:

2012-07-01

Pagination or Media Count:

9.0

Abstract:

In mammals and other higher eukaryotes, SRA-RING proteins are essential for global maintenance of DNA methylation. This research project focuses on the discovery of new ubiquitination targets for the Arabidopsis SRA-RING protein VIM1 and the human SRA-RING protein UHRF1. Additionally, it will closely examine the methylcytosinebinding specificity of UHRF1, with a specific focus on non-CpG contexts. The proposed work is ongoing, and so far the major accomplishments include creation of relevant plant lines and development of in vitro assays.

Descriptors:

• *CHROMATIN
• *DEOXYRIBONUCLEIC ACIDS
• *METHYLATION
• *PROTEINS
• GENOME
• HISTONES
• IN VITRO ANALYSIS
• MAMMALS
• PLANTS(BOTANY)

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE