Accession Number:

ADA566728

Title:

Nano-Engineered Drug Combinations for Breast Cancer Treatment

Descriptive Note:

Annual rept. 15 May 2011-14 May 2012

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

• Lahann, Joerg

Report Date:

2012-06-01

Pagination or Media Count:

10.0

Abstract:

We hypothesis that nanoparticles can increase the efficacy of combination therapies for cancer. The project aims to explore nanoparticle-based transport vehicles for effective delivery of two different cancer drugs. In particular, we aim to use two breast cancer drugs, which enhance each other s efficacy and use them as a model drug pair for the development of novel dual-drug nano-therapeutics. The research to date has been focused on extending existing electrohydrodynamic co-jetting technology in the Lahann lab towards the simultaneous release of two independent small molecule drug surrogates.

Descriptors:

• *BREAST CANCER
• *ELECTROHYDRODYNAMICS
• *NANOPARTICLES
• CARGO VEHICLES
• DELIVERY
• DRUGS
• HYPOTHESES
• LABORATORIES
• MOLECULES
• RELEASE
• SYNCHRONISM
• THERAPY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE