Accession Number:

ADA566717

Title:

Measuring Intracranial Pressure and Correlation with Severity of Blast Traumatic Brain Injury

Descriptive Note:

Annual rept. 16 Seo 2919015 Sep 2011

Corporate Author:

METROPOLITAN DETROIT RESEARCH AND EDUCATION DETROIT MI

Personal Author(s):

• VandeVord, Pamela

Report Date:

2011-10-01

Pagination or Media Count:

35.0

Abstract:

A greater understanding of the mechanisms of TBI due from overpressure exposure is critical to develop effective protection and treatments. Fundamental, yet unresolved, questions concern the mode of blast energy transfer to the brain as well as the consequent damage or disruptive mechanisms at the cellular level. The ultimate goal of this research effort is to determine the intracranial pressure ICP responses to blast exposure. The objective of this research is to understand how pressure is transmitted through the brain and ascertain the relationship between levels of pressure transmission with severity of brain injury. Several biomechanical parameters were investigated during this year of the proposal. We used a shock tube model in which instrumented animals were be subjected to a series of systematic shocktube studies of blast-stress transmission to the brain. We demonstrated by this series of tests that the brain-skull system is very sensitive to instrumentation location. Furthermore, we documented that the skull undergoes strain and deformation when exposed to the transient shock wave. Overall, the data key to determining the mechanism of blast energy transmission

Descriptors:

• *MEASUREMENT
• *TRAUMATIC BRAIN INJURIES
• BIOMECHANICS
• BLAST
• DAMAGE
• DEFORMATION
• ENERGY TRANSFER
• INSTRUMENTATION
• OVERPRESSURE
• PARAMETERS
• SHOCK TUBES
• SHOCK WAVES
• SKULL
• TRAUMA
• WOUNDS AND INJURIES

Subject Categories:

• Medicine and Medical Research
• Numerical Mathematics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE