Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury
Final rept. 1 Jun 2009-31 May 2011
LOMA LINDA UNIV CA
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To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury mTBI i hyperbaric oxygen HBO preconditioning and ii HBO treatment combined with intranasal delivery of nicotinamide NAD. Scope In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times 3, 7d using non-invasive MRI assessments T2WI, SWI, and DTI, correlated with histology. The effects of i a prophylactic HBO strategy pretreatment 3d X 1hr prior to first mTBI and ii the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of NAD right after the first mTBI impact will be evaluated using the MRI and histological biomarkers.
- Medicine and Medical Research
- Weapons Effects (Biological)