Accession Number:

ADA566666

Title:

Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury

Descriptive Note:

Final rept. 1 Jun 2009-31 May 2011

Corporate Author:

LOMA LINDA UNIV CA

Personal Author(s):

• Obenaus, Andre

Report Date:

2011-06-01

Pagination or Media Count:

120.0

Abstract:

To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury mTBI i hyperbaric oxygen HBO preconditioning and ii HBO treatment combined with intranasal delivery of nicotinamide NAD. Scope In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times 3, 7d using non-invasive MRI assessments T2WI, SWI, and DTI, correlated with histology. The effects of i a prophylactic HBO strategy pretreatment 3d X 1hr prior to first mTBI and ii the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of NAD right after the first mTBI impact will be evaluated using the MRI and histological biomarkers.

Descriptors:

• *TRAUMATIC BRAIN INJURIES
• HISTOLOGY
• HYPERBARIC CONDITIONS
• MAGNETIC RESONANCE IMAGING
• PREVENTIVE MEDICINE
• RATS
• TEST AND EVALUATION
• THERAPY
• TRACER STUDIES

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE