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Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury
Annual rept. 30 Sep 2010-29 Sep 2011
STATE UNIV OF NEW YORK DOWNSTATE MEDICAL CENTER BROOKLYN
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Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury TBI. The grantee previously found screened that the combination of minocycline MINO and N-acetyl cysteine NAC synergistically improved brain function when dosed one hour following closed cortical impact CCI in rats. The overall objective of this proposal is that MINONAC synergistically improves brain function following TBI. Four tasks will be done to achieve this objective 1 Differing doses of MINONAC will be tested for the ability to improve behavior and histology following moderate CCI. 2 MINONAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. 3 TBI is clinically heterogenous MINONAC should restore brain function following an additional TBI model, lateral fluid percussion. 4 A restoration of cognitive function will be tested three months after CCI. The grantee has received both institutional and DoD approval for the animal experiments in this work and has trained a MD-Ph.D. candidate to perform these studies.
APPROVED FOR PUBLIC RELEASE