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Human Neural Cell-Based Biosensor
Quarterly technical rept. 1 Jul-30 Sep 2012
ARUNA BIOMEDICAL INC ATHENS GA
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The purpose of this project is to develop in vitro, cell based biosensors for environmental toxins. By using ArunA s neural cell lines derived from both human embryonic stem cells hESCs and human induced pluripotent stem cells hiPSCs, our goal is to provide a human neural cell based biosensor that is a more biologically relevant model of human physiology. This report describes the progress made in these major areas 1 directed differentiation of hESC- and hiPSC-derived neural progenitor cells into dopaminergic neurons 2 directed differentiation of hESC- and hiPSC-derived neural progenitor cells into astrocytes 3 cell culture medium development for the maintenance and differentiation of ArunA s neural cell lines as sensor elements for neurotoxicity and 4 label-free, adhesive signature-based microfluidic cell separation.
APPROVED FOR PUBLIC RELEASE