Accession Number:

ADA566089

Title:

In Search of an Effective in vivo Reactivator for Organophosphorus Nerve Agent-Inhibited Acetylcholinesterase in the Central Nervous System

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD PHARMACOLOGY BRANCH

Report Date:

2012-01-01

Pagination or Media Count:

29.0

Abstract:

Organophosphorus nerve agents irreversibly inhibit the enzyme acetylcholinesterase AChE, leading to excessive cholinergic neurotransmission and causing toxic lethal consequences. Current nerve agent therapies in the U.S. include 2-pralidoxime to reactivate inhibited AChE. Due to its quaternary structure, this oxime does not readily cross the blood brain barrier BBB to reactivate brain AChE and to mitigate CNS toxicity.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE