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Development of a Hybrid Optical Biopsy Probe to Improve Prostate Cancer Diagnosis
Annual rept. 1 Jun 2009-31 May 2010
TEXAS UNIV AT ARLINGTON
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Hypothesis a multi-modal optical spectroscopic method and an integrated needle probe can be developed for guiding needle biopsy for prostate cancer diagnosis. Multi-modal optical measurements to be utilized for the study are 1 light scattering spectroscopy LSS, 2 auto-fluorescence spectroscopy AFS, and 2 auto-fluorescence life-time measurements AFLT. Our specific aims are Aim 1 to develop a multi-modal, optical spectroscopic instrument, which allows the measurements of 1 LSS, 2 AFS, and 3 AFLT. The proposed system will be portable, can be used for in vivo measurements, and collect and present the data in real time. Aim 2 to integrate the optical fibers, which collect light scattering and auto-fluorescence from the prostate tissue, into a transrectal-ultrasound, needle-biopsy probe. In the development phase, the optical signatures of prostate cancer can be collected with the biopsy tissues and identified along every tract of needle biopsies. Aim 3 to collect optical signals of control and cancer tissues ex vivo along with the regular human needle biopsy, followed by classification algorithm development to discriminate cancer tissues. Aim 4 to perform in vivo measurement from human subjects to obtain the accuracy and sensitivity of the integrated probe in order to provide real-time, on-site, improved guidance for prostate cancer tissue biopsy.
APPROVED FOR PUBLIC RELEASE