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Development of a Novel Microfluidic Platform for Multiple Sclerosis Study
Final rept. 15 Jul 2011-14 Jul 2012
JOHNS HOPKINS UNIV BALTIMORE MD
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Neural stem cells NSC are multipotent cells isolated from striatal tissue and the subventricular zone, which is one of a few neurogenic areas in the adult brain. Evidence suggests that NSC proliferation and differentiation occur under physiological conditions and can be enhanced in certain pathological conditions following neural damage. However, the communication between soluble factors of inflammatory T cells and NSCs that affect the proliferation and differentiation of NSCs remain unknown. The goal of this project is to develop a novel NSC culture platform that is capable of both compartmentalizing and fluidically isolating microdomains of NSCs.
APPROVED FOR PUBLIC RELEASE