Accession Number:

ADA564418

Title:

Development of a Novel Microfluidic Platform for Multiple Sclerosis Study

Descriptive Note:

Final rept. 15 Jul 2011-14 Jul 2012

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

• Yang, In H.

Report Date:

2012-08-01

Pagination or Media Count:

6.0

Abstract:

Neural stem cells NSC are multipotent cells isolated from striatal tissue and the subventricular zone, which is one of a few neurogenic areas in the adult brain. Evidence suggests that NSC proliferation and differentiation occur under physiological conditions and can be enhanced in certain pathological conditions following neural damage. However, the communication between soluble factors of inflammatory T cells and NSCs that affect the proliferation and differentiation of NSCs remain unknown. The goal of this project is to develop a novel NSC culture platform that is capable of both compartmentalizing and fluidically isolating microdomains of NSCs.

Descriptors:

• *NERVOUS SYSTEM DISEASES
• *PHYSIOLOGICAL EFFECTS
• BRAIN
• CELLS(BIOLOGY)
• COMMUNICATION AND RADIO SYSTEMS
• CULTURES(BIOLOGY)
• DAMAGE
• NERVOUS SYSTEM
• STEM CELLS
• T LYMPHOCYTES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE