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Quantification of Protein Signatures in Archived Human Prostate Tissues Using Shotgun Proteomic Methods
Annual rept. 1 Aug 2011-30 Apr 2012
IOWA UNIV IOWA CITY
Pagination or Media Count:
Biomarkers that robustly predict the metastatic potential of localized CaP are sorely needed to effectively treat localized CaP patients that pose the greatest risk of developing significant CaP. Biomarkers specific to significant CaP are also necessary if more effective drugs are going to be developed that can target and cure patients afflicted by this deadly disease. Proteins represent some of the most powerful molecular biomarkers to human disease such as cancer. Therefore this proposal will implement state-of-the-art methods in biological mass spectrometry to identify protein biomarkers specific to non-significant and significant CaP. These new protein biomarkers may spur the development of molecular tests that robustly predict the metastatic potential of non-significant CaP. These tests would reduce the physical and mental burdens associated with the overtreatment of patients afflicted by localized CaP. Also, protein biomarkers specific to significant CaP may represent new and effective drug targets to cure patients already afflicted by this deadly disease. We anticipate this proposal will identify the critical molecular targets with the greatest potential to improve the treatment and potentially cure CaP in men.
APPROVED FOR PUBLIC RELEASE