Accession Number:

ADA564012

Title:

Loss of PTEN as a Predictive Biomarker of Response to Lithium Chloride, A Potential Targeted Treatment for Breast Cancer

Descriptive Note:

Annual summary 1 Jun 2011-31 May 2012

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

• Higgins, Michaela

Report Date:

2012-06-01

Pagination or Media Count:

11.0

Abstract:

During the second year of this project, Tasks 1c and 2a have been completed. This includes biochemical and phenotypical characterization of isogenic breast cell lines with heterozygous and homozygous PTEN loss and a library of other cell lines which each represent a distinct mutation of the PI3KmTOR pathway. Exposure of various isogenic pairs of PTEN knock out cell lines to lithium chloride has also been completed.

Descriptors:

• *BREAST CANCER
• BIOCHEMISTRY
• CELLS(BIOLOGY)
• LITHIUM CHLORINE CELLS
• MAMMARY GLANDS
• RESPONSE

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE