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Loss of PTEN as a Predictive Biomarker of Response to Lithium Chloride, A Potential Targeted Treatment for Breast Cancer
Annual summary 1 Jun 2011-31 May 2012
MASSACHUSETTS GENERAL HOSPITAL BOSTON
Pagination or Media Count:
During the second year of this project, Tasks 1c and 2a have been completed. This includes biochemical and phenotypical characterization of isogenic breast cell lines with heterozygous and homozygous PTEN loss and a library of other cell lines which each represent a distinct mutation of the PI3KmTOR pathway. Exposure of various isogenic pairs of PTEN knock out cell lines to lithium chloride has also been completed.
APPROVED FOR PUBLIC RELEASE