Accession Number:

ADA562179

Title:

Botulinum Neurotoxins

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD INTEGRATED TOXICOLOGY DIVISION

Report Date:

2012-03-28

Pagination or Media Count:

27.0

Abstract:

Botulism is a neuroparalytic disease caused by neurotoxin produced from the bacterium Clostridium botulinum. The botulinum neurotoxins BoNTs are among the most potent known biological toxins and have an estimated human median lethal dose LD50 in the nanogramkilogram range. Botulinum toxins have historically been employed as biological weapons BW through state-sponsored programs in Japan, Germany, the United States, Russia and Iraq as well as by independent terrorist organizations. The extreme potency of the toxin, its persistence within affected neurons, the need for protracted intensive care, and the lack of an effective post-intoxication therapeutic intervention make BoNTs a potentially deadly offensive biological weapon.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE