Desferrioxamine for Stimulation of Fracture Healing and Revascularization in a Bone Defect Model
Final rept. 30 Sep 2010-29 Jan 2012
NORTH CAROLINA UNIV AT CHAPEL HILL
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Our study explored local delivery of deferroxamine with and without bone allograft as a means to accelerate fracture healing in a tibia defect model of the rat. Experimental groups in the first study included control, CS calcium sulfate annulus around spacer at defect, CSDBA CS implant and demineralized bone allograft DBA CSDFO DFO 300 g loaded CS implant, CSDFODBA DFO loaded CS implant with DBA allograft. Experimental groups in the second study included control, DBA, LDFO DBA DBA soaked with DFO 10 g, H-DFODBA DBA soaked with DFO 100ug. Fractures were evaluated at 6 weeks postinjury for radiographic cortical bridging, CT mineralized callus volume and torsional properties. The bulk CS annulus was found to impair healing compared to the control in the 1st study. In the 2nd study L-DFODBA was found to increase cortical bridging and torsional strength relative to the control. Bulk form CS is not an effective method of delivery of DFO to stimulate fracture healing. Low dosage DFO treatment directly to DBA was found to enhance the ability of DBM to stimulate fracture healing, while higher dosage DFO treatment of DBA was not effective.
- Anatomy and Physiology
- Medicine and Medical Research