Accession Number:

ADA561970

Title:

Plasma Endothelial Microparticles in Multiple Sclerosis: A Novel Metric Assay of Disease Activity and Response to Treatment

Descriptive Note:

Revised annual rept. 1 Sep 2010-31 Aug 2011

Corporate Author:

LOUISIANA STATE UNIV IN SHREVEPORT HEALTH SCIENCE CENTER

Personal Author(s):

• Alexander, Jonathan S.
• Minagar, Alireza

Report Date:

2011-09-01

Pagination or Media Count:

222.0

Abstract:

The purpose of this research project is to validate plasma microparticle profiling in multiple sclerosis with the goal of defining microparticle species which have value as predictive or prognostic biomarkers. Additionally, the findings of this project Scope These finding apply to both civilian and military patients with MS. Major Findings We have now linked iron deposits in specific brain structures in MS with particular microparticle species some of these data have been presented at the last international society for neurovascular disease. Up to date report We are continuing with patient recruitment and processing of samples and are collecting timed patient samples after recruitment towards completion of the project.

Descriptors:

• *ENDOTHELIUM
• *NERVOUS SYSTEM
• *RESPONSE(BIOLOGY)
• BLOOD VESSELS
• BRAIN
• DISEASES
• INFLAMMATION
• IRON
• MILITARY PERSONNEL
• PARTICLES
• PATIENTS
• PLASMAS(PHYSICS)

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE