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Direct Inhibition of Skp2 for the Treatment of Advanced Prostate Cancer
Final rept. 1 May 2011-30 Apr 2012
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
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The goal of this project is to identify molecules that block the growth of late stage prostate cancer cells through the inhibition of Skp2 signaling. To this end, we performed a high-throughput screening of cyclic peptoid libraries, resulting in the identification of two molecules that directly bind Skp2. These compounds were found to effectively reduce cell viability of cancerous cells. With the compelling preliminary results, further studies are now in progress to evaluate their activity of the compounds as a novel class of anti-prostate cancer agents.
APPROVED FOR PUBLIC RELEASE