Accession Number:

ADA561907

Title:

Direct Inhibition of Skp2 for the Treatment of Advanced Prostate Cancer

Descriptive Note:

Final rept. 1 May 2011-30 Apr 2012

Corporate Author:

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

Personal Author(s):

• Lim, Hyun-Suk

Report Date:

2012-05-01

Pagination or Media Count:

7.0

Abstract:

The goal of this project is to identify molecules that block the growth of late stage prostate cancer cells through the inhibition of Skp2 signaling. To this end, we performed a high-throughput screening of cyclic peptoid libraries, resulting in the identification of two molecules that directly bind Skp2. These compounds were found to effectively reduce cell viability of cancerous cells. With the compelling preliminary results, further studies are now in progress to evaluate their activity of the compounds as a novel class of anti-prostate cancer agents.

Descriptors:

• *GROWTH(PHYSIOLOGY)
• *INHIBITION
• *PROSTATE CANCER
• CELLS(BIOLOGY)
• HIGH RATE
• IDENTIFICATION
• SELECTION

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE