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The CXCR/EGFR Axis in the Initiation and Progression of Prostate Cancer
Annual summary rept. 15 Apr 2011-14 Apr 2012
MICHIGAN UNIV ANN ARBOR
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CXCL12 is a small molecular weight protein secreted by fibroblasts in the prostate stroma consequent to aging and activates CXCR4, a G-protein coupled receptor expressed in prostate epithelial cells. Activation of the CXCL12CXCR4 axis has been shown to promote prostate cancer cell proliferation, motility, and invasiveness furthermore, previous reports have shown phosphorylation of EGFR and HER2 in response to CXCL12 treatment. Here I examined the dimerization of EGFR and HER2 in response to varying concentrations of CXCL12. Although some instances of heterodimerization were observed using co-IP, there was no consistency in responses to specific concentrations and observed dimerization with CXCL12 treatment was not as robust as with EGF treatment thus, these data are inconclusive and I am unable to report novel significant findings.
APPROVED FOR PUBLIC RELEASE