Accession Number:

ADA561859

Title:

Pathogenesis of Acute and Delayed Corneal Lesions After Ocular Exposure to Sulfur Mustard Vapor

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Personal Author(s):

• McNutt, Patrick
• Hamilton, Tracey
• Nelson, Marian
• Adkins, Angela
• Swartz, Adam
• Lawrence, Richard
• Milhorn, Denise

Report Date:

2012-03-01

Pagination or Media Count:

12.0

Abstract:

Sulfur mustard SM exposure results in dose-dependent morbidities caused by cytotoxicity and vesication. Although lesions resulting from ocular exposure often resolve clinically, an idiopathic delayed mustard gas keratopathy MGK can develop after a moderate or severe exposure. Sequelae include persistent keratitis, recurring epithelial lesions, corneal neovascularization, and corneal degeneration, which can lead to impaired vision or loss of sight. The purpose of this effort is to correlate structural changes with injury progression during the development of MGK.

Descriptors:

• *CORNEA
• *EXPOSURE(PHYSIOLOGY)
• *MUSTARD AGENTS
• *PATHOGENESIS
• *SULFUR
• BLOOD VESSELS
• CHEMICAL WARFARE AGENTS
• CYTOTOXINS
• GROWTH(PHYSIOLOGY)
• VAPORS
• VISION

Subject Categories:

• Medicine and Medical Research
• Toxicology
• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE