Accession Number:

ADA561549

Title:

Early Breast Lesion Typing With Hyperpolarized Choline, Benign Or Malignant

Descriptive Note:

Annual rept. 1 Feb 2011-31 Jan 2012

Corporate Author:

CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA

Personal Author(s):

• Wagner, Shawn

Report Date:

2012-02-01

Pagination or Media Count:

8.0

Abstract:

This work is focused on developing a breast cancer biomarker utilizing magnetic resonance spectroscopyimaging and hyperpolarization. I have initiated and completed most of the elements in the first part of the project which consist of developing the equipment and the biomarker agent. Task 2-4 required the completion of Task 1. The most significant achievement is the completion of the required equipment and initial testing. We have developed a fully functional parahydrogen induced polarization PHIP instrument and verified the functionality with a PHIP agent. Task 1 a the development of a fixed field magnet was abandoned due to construction difficulties and better alternative solution to allowing us to generate a stable homogeneous magnetic field with a current controlled solenoid. This project was extended 6 months due to delivery problems for the required transgenic mice. We are on schedule to begin and complete Task 2-4, the in vivo an in vitro proof of concept testing of the accumulation of 15N-Iabeled choline analog in breast cancer cells by hyperpolarized 15N.

Descriptors:

• *BREAST CANCER
• *LESIONS
• *MAGNETIC RESONANCE IMAGING
• *SPECTROSCOPY
• CONSTRUCTION
• DELIVERY
• HOMOGENEITY
• IN VITRO ANALYSIS
• IN VIVO ANALYSIS
• MAMMARY GLANDS
• SCHEDULING
• TRANSCRIPTION(GENETICS)

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE