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Early Support of Intracranial Perfusion
Annual rept. 17 Sep 2010-16 Sep 2011
MARYLAND UNIV BALTIMORE
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This report represents the fourth in a multi-year effort to improve outcomes in patients with traumatic brain injury TBI utilizing human and animal models. The first two years focused on infrastructure development, human use and basic science protocol development, staff acquisition, equipment purchase and database development. At the conclusion of Year 2, two human use protocols focusing on the inflammatory process following TBI and vital sign response to trauma had been instituted development and testing of the Brain Resuscitation Registry BRR to provide structure and linkage capabilities for data collection and outcome reporting continued, and the animal sub-project underwent further development and re-formatting. Year 3 accomplishments included the ongoing enrollment of subjects in the human use protocols, development and implementation of 2 retrospective human use protocols, processing of specimens for the Cytokines sub-project, further development of the BRR and initiation of the basic science model including both small and large animal models of polytrauma. During Year 4 the existing human use protocols concluded data collection and neared finalization of data analysis, and a new protocol proposed. Progress continued in BRR development and reporting, and the animal sub-project neared completion. An additional no-cost extension was granted in August 2011, to allow for implementation of the final human use protocol and completion of data analysis.
APPROVED FOR PUBLIC RELEASE