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Early Support of Intracranial Perfusion
Annual rept. 17 Sep 2008-16 Sep 2009
MARYLAND UNIV BALTIMORE
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This report represents the second year in a multi-year effort to improve outcomes in patients with traumatic brain injury TBI. This project utilizes human and animal models in an effort first to identify what factors are important in determining outcome from TBI and secondly to test new techniques in patient care. Year 1 focused on development of an infrastructure for gathering data in TBI patients, development of a protocol to advance understanding of the inflammatory process which follows TBI, and creation of a basic science model of brain trauma. Staff were hired and assigned, equipment purchased and protocols and databases developed. Year 2 has seen the implementation of two human use protocols, on-going development and testing of the Brain Resuscitation Registry BRR to provide structure and linkage capabilities for data collection and outcome reporting, and further development and re-formatting of the animal model sub-project. IRB protocols for year 3 projects are being developed for submission, equipment server and computer tablets purchased to allow the implementation of the BRR and assay kits ordered to allow the processing of specimens collected as part of the Cytokines sub-project. The basic science model was revised during Year 2 and now reflects both small and large animal models of polytrauma
APPROVED FOR PUBLIC RELEASE