Accession Number:

ADA561372

Title:

Biomarker Discovery and Mechanistic Studies of Prostate Cancer Using Targeted Proteomic Approaches

Descriptive Note:

Annual rept. 1 Jul 2010-30 Jun 2011

Corporate Author:

KENTUCKY UNIV LEXINGTON

Personal Author(s):

• Kyprianou, Natasha
• Zhu, Haining

Report Date:

2011-07-01

Pagination or Media Count:

11.0

Abstract:

Our findings reveal that EMMPRIN immunoreactivity was primarily detected among the glandular epithelial cells EMMPRIN levels progressively increased with increasing age of TRAMP mice 6-27wks with the highest detected in liver metastases. Quantitative analysis revealed that by 27-wks an age exhibiting highly aggressive prostate tumor phenotype, EMMPRIN expression increased significantly P0.001. These results suggest that EMMPRIN may have diagnostic value in prostate cancer detection in advanced disease.

Descriptors:

• *METASTASIS
• *PROSTATE GLAND
• CELLS(BIOLOGY)
• DIAGNOSIS(MEDICINE)
• DISEASES
• EPITHELIUM
• GLANDS
• GROWTH(PHYSIOLOGY)
• LIVER
• NEOPLASMS

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE