Accession Number:

ADA561087

Title:

Oxidative Stress, DNA Repair, and Prostate Cancer Risk

Descriptive Note:

Revised final rept. 1 Aug 2008-31 Jul 2011

Corporate Author:

HEALTH RESEARCH INC BUFFALO NY

Personal Author(s):

• Zhao, Hua

Report Date:

2011-08-01

Pagination or Media Count:

11.0

Abstract:

Oxidative stress, which results from an imbalance between ROS and antioxidant capacities, can cause a wide range of direct or indirect DNA damage. There are extensive DNA repair systems that can correct DNA damage caused by ROS before cell replication and mutation fixation. Although oxidative stress appears to be important in the etiology of prostate cancer, so far there is no study to comprehensively investigate the association between DRC of oxidative DNA damage as a phenotype and prostate cancer risk. We hypothesize that DRC of oxidative DNA damage as a phenotype may modify prostate cancer risk. We have completed the analysis of DRC in 350 prostate cancer patients and 350 healthy controls. Overall, we didn t observe any significant association between DRC and prostate cancer risk. Therefore, we have concluded that DRC is not a risk factor for prostate cancer

Descriptors:

• *DEOXYRIBONUCLEIC ACIDS
• *OXIDATION
• *PROSTATE CANCER
• ANTIOXIDANTS
• DAMAGE
• ETIOLOGY
• MUTATIONS
• PATIENTS
• RISK
• STRESSES

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE