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Canonical Wnt Signaling as a Specific Marker for Normal and Tumorigenic Mammary Stem Cells
VAN ANDEL RESEARCH INSTITUTE GRAND RAPIDS MI
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We have determined that the WntB-catenin signaling pathway is active within a small subset of cells within the mammary gland. This small subset is entirely contained within the previously identified population that has the ability to repopulate a cleared mammary fat pad. Thus, activation of canonical Wnt signaling may be a very specific marker for mammary stem cells and be a target for transformation that results in the formation of aggressive mammary tumors.
APPROVED FOR PUBLIC RELEASE