Accession Number:

ADA561084

Title:

Canonical Wnt Signaling as a Specific Marker for Normal and Tumorigenic Mammary Stem Cells

Descriptive Note:

Annual rept.

Corporate Author:

VAN ANDEL RESEARCH INSTITUTE GRAND RAPIDS MI

Personal Author(s):

• Williams, Bart

Report Date:

2012-02-01

Pagination or Media Count:

14.0

Abstract:

We have determined that the WntB-catenin signaling pathway is active within a small subset of cells within the mammary gland. This small subset is entirely contained within the previously identified population that has the ability to repopulate a cleared mammary fat pad. Thus, activation of canonical Wnt signaling may be a very specific marker for mammary stem cells and be a target for transformation that results in the formation of aggressive mammary tumors.

Descriptors:

• *BREAST CANCER
• *STEM CELLS
• ACTIVATION
• CELLS(BIOLOGY)
• MAMMARY GLANDS
• NEOPLASMS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE