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Differential Expression of Zinc Transporters in Prostate Epithelia of Racial Groups

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Annual rept. 1 Sep 2009-31 Aug 2010

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In the award W81XWH-08-1-0627 the stated goals are to study the zinc transporters that may be disparately expressed in the prostate tissues of African American AA males as compared to European American EA males. This may lead to identification of the potential molecular targets for preventive or therapeutic measures or nutritional, environmental or life style factors for their potential relationship to the incidence or progression of prostate cancer in various racial groups. The following tasks are to be carried out in a synergistic fashion between the laboratories of Dr. Bagasra Claflin University and Dr. Balla University of Illinois, Chicago. The prostate tissues, pre-made tissue microarrays TMAs and primary cell lines will be obtained from the NCI -initiated Cooperative Prostate Cancer Tissue Resource CPCTR by Dr. Balla, one of the P.I.s of the present proposal and of the CPCTR. The main tissue microarray being used is composed of age-matched and the Gleason score-matched prostate tissues with representative tissues from 150 African Americans and 150 European American racial groups. Other TMAs are also used to address questions of whether hZIP gene and protein expression is associated with poor outcome andor Gleason grade. Significant progress has been made in each of the three TASKS proposed. So far we have two peerreviewed publications as well as numerous oral and poster presentations have resulted. We also have three additional publications in preparation for peer-review journals.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

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