Accession Number:

ADA561069

Title:

Abnormal Vestibulo-Ocular Reflexes in Autism: A Potential Endophenotype

Descriptive Note:

Annual rept. 15 May 2010-14 May 2011

Corporate Author:

FLORIDA UNIV GAINESVILLE

Personal Author(s):

• White, Keith

Report Date:

2011-06-01

Pagination or Media Count:

46.0

Abstract:

The overarching objective of this study is to characterize abnormalities of vestibulo-ocular reflexes VOR in Autism Spectrum Disorder ASD. Specific Aim 1 Characterize horizontal VOR post-rotary nystagmus without optokinetic feedback using a velocity step test. We hypothesize that in ASD vertical eye movement intrusions during horizontal nystagmus will occur more frequently than normal, will be time-locked to horizontal nystagmus, and will differ from voluntary saccades. Specific Aim 2 Characterize horizontal VOR without optokinetic feedback using sinusoidal oscillation tests. We hypothesize that gain and phase lag of horizontal VOR will differ in children with ASD compared to controls. Specific Aim 3 Characterize in ASD vertical VOR and torsional VOR, both without optokinetic feedback. Because neither of these aspects of the VOR have been described previously in ASD, Aim 3 is exploratory.

Descriptors:

• *ABNORMALITIES
• *MENTAL DISORDERS
• CHILDREN
• DEVELOPMENTAL PSYCHOLOGY
• EYE MOVEMENTS
• NYSTAGMUS
• REFLEXES
• TORSION

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE