Characterization and Application of a Large Animal Model of Penetrating Ballistic Brain Injury (PBBI)
Annual rept. 15 Feb 2011-14 Feb 2012
TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
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The Purpose of the proposal titled Characterization and Application of a Large Animal Model of Penetrating Ballistic Brain Injury PBBI is to develop a large animal model with military relevance. Of military casualties with moderate to severe traumatic brain injuries TBI 15-18 are due to penetrating mechanisms. Almost all 97 of prospective clinical trials of TBI exclude patients with PBBI and no prospective clinical trials specifically focus on PBBI. A large animal model of PBBI will enable the initial assessment of products and procedures that were developed for blunt TBI to be assessed for safety and efficacy in a penetrating model. This project will characterize the profiles of PBBI s physiology and histopathology with increasing magnitudes of injury. The investigators hypothesize that in swine, PBBI will cause tissue damage, inflammation and coagulopathy, and that the extent of these changes will depend on the percent of cavitation related to brain volume. Animal use approvals have been obtained and initial studies have been completed in Yorkshire swine to develop the model and verify assays and antibodies. The project is on schedule and is currently undergoing further studies in the Sinclair swine.
- Medicine and Medical Research