Accession Number:
ADA558975
Title:
A Physiological Systems Approach to Modeling and Resetting of Mouse Thermoregulation under Heat Stress
Descriptive Note:
Journal article
Corporate Author:
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION
Personal Author(s):
Report Date:
2011-09-01
Pagination or Media Count:
9.0
Abstract:
Heat stroke HS is a serious civilian and military health issue. Due to the limited amount of experimental data available in humans, this study was conducted on a mouse mathematical model fitted on experimental data collected from mice under HS conditions, with the assumption there is good agreement among mammals. Core temperature Tc recovery responses in a mouse model consist of hypothermia and delayed fever during 24 h of recovery that represent potential biomarkers of HS severity. The objective of this study was to develop a simulation model of mouse Tc responses and identify optimal treatment windows for HS recovery using a three-dimensional predictive heat transfer simulation model. Several bioenergetic simulation variables, including nonlinear metabolic heat production Wcu m, temperature-dependent convective heat transfer through blood mass perfusion Wcu m, and activity-related changes in circadian Tc were used for model simulation. The simulation results predicted the experimental data with few disparities. Using this simulation model, we tested a series of ambient temperature treatment strategies to minimize hypothermia and delayed fever to accelerate HS recovery. Using a genetic algorithm, we identified eight time segments ambient temperature 27, 30, 31, 29, 28, 28, 27, 26 deg C of 110 min total duration that optimized HS recovery in our model simulation.
Descriptors:
Subject Categories:
- Stress Physiology