Accession Number:

ADA558975

Title:

A Physiological Systems Approach to Modeling and Resetting of Mouse Thermoregulation under Heat Stress

Descriptive Note:

Journal article

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION

Report Date:

2011-09-01

Pagination or Media Count:

9.0

Abstract:

Heat stroke HS is a serious civilian and military health issue. Due to the limited amount of experimental data available in humans, this study was conducted on a mouse mathematical model fitted on experimental data collected from mice under HS conditions, with the assumption there is good agreement among mammals. Core temperature Tc recovery responses in a mouse model consist of hypothermia and delayed fever during 24 h of recovery that represent potential biomarkers of HS severity. The objective of this study was to develop a simulation model of mouse Tc responses and identify optimal treatment windows for HS recovery using a three-dimensional predictive heat transfer simulation model. Several bioenergetic simulation variables, including nonlinear metabolic heat production Wcu m, temperature-dependent convective heat transfer through blood mass perfusion Wcu m, and activity-related changes in circadian Tc were used for model simulation. The simulation results predicted the experimental data with few disparities. Using this simulation model, we tested a series of ambient temperature treatment strategies to minimize hypothermia and delayed fever to accelerate HS recovery. Using a genetic algorithm, we identified eight time segments ambient temperature 27, 30, 31, 29, 28, 28, 27, 26 deg C of 110 min total duration that optimized HS recovery in our model simulation.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE