Accession Number:

ADA558816

Title:

Early Assessment of Breast Cancer Therapy Response Using Photoacoustic Molecular Imaging

Descriptive Note:

Annual summary rept. 1 Jan-31 Dec 2010

Corporate Author:

LELAND STANFORD JUNIOR UNIV CA

Personal Author(s):

Report Date:

2011-01-01

Pagination or Media Count:

32.0

Abstract:

The purpose of this grant is to build instrumentation and imaging agents for photoacoustic imaging of breast cancer, using which one could estimate the change in molecular expression of various breast-cancer-specific proteins undergoing chemotherapy treatment. Weve made significant progress towards obtaining this goal 1 we have adapted our instrumentation hardware and image reconstruction software for allowing to acquire photoacoustic images of multiple contrast agents simultaneously 2 We developed several new contrast agents based on carbon nanotubes and showed they exhibit 300-times higher sensitivity and for the first allow imaging photoacoustic molecular probes at sub-nanomolar concentrations one paper published in Nano Letters and another was submitted to Nano Letters as well.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE