Hsf1 in Her2-positive Breast Cancer
Annual rept. 15 Jan 2010-14 Jan 2011
BOSTON UNIV MEDICAL CAMPUS MA
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In the first year of the grant we addressed tasks 1, 2 and 3. Specifically we demonstrated that Hsf1 controls development of Her2-positive cancer both at the stage of initiation, where is affects the oncogene-induced senescence, and later at the stage of progression, where it affects tumor angiogenesis. We also dissected the mechanism of effects of Hsf1 on tumor angiogenesis, and demonstrated that Hsf1 regulates expression of the major angiogenesis factor HIF-1.
- Medicine and Medical Research