Oxygenation-Enhanced Radiation Therapy of Breast Tumors
Final rept. 1 Sep 2010-31 Oct 2011
UTAH UNIV SALT LAKE CITY
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The treatment of locoregional breast cancer has evolved from radical mastectomy to targeted local therapy with breast conservation. The efficacy of conserving treatments of breast cancers is impeded by tumor hypoxia, which affects 50 of locally advanced breast tumors. Poor oxygenation of hypoxic tumors reduces their sensitivity to X-ray and -radiation, which requires a high radiation dose for efficacy compared to normally oxygenated tissues. This Concept project provides initial investigation the method for targeted oxygen release from oxygen carriers as a step towards as a novel strategy of radio sensitization of hypoxic breast tumors, and studies the effect of different targeting mechanisms on the oxygen mass transfer. Specific results include the development of stabilized perfluorocarbon emulsions as oxygen carriers, their characterization, and response to external triggers, including elevated temperature, reduced pressure, and dwell time.
- Medicine and Medical Research