Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury
Annual rept. 27 Sep 2010-26 Sep 2011
DREXEL UNIV PHILADELPHIA PA
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Spinal cord injuries SCI produce direct mechanical disruption and subsequent severe degeneration of axons these processes cause the associated neurologic deficits. Histological studies of fixed tissue in animal models of SCI have described axonal loss and demyelination. Research at the U. Penn site brings novel magnetic resonance methodology to bear with the objective of obtaining quantitative information on axonal degeneration and myelin loss following SCI in a mouse model by pursuing the following specific aims per the work statement 1. We will perform q-space MR imaging QSI and simulations of QSI to quantify axonal architecture in healthy and injured mouse spinal cords. 2. We will quantify myelin content with three quantitative MRI techniques in healthy and injured mouse spinal cords and compare the results with histology.
- Anatomy and Physiology
- Medicine and Medical Research