Accession Number:

ADA558404

Title:

Ultrasound-Based Guidance for Partial Breast Irradiation Therapy

Descriptive Note:

Annual summary 1 Jan 2009-31 Dec 2011

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

Report Date:

2012-01-01

Pagination or Media Count:

81.0

Abstract:

Tracked ultrasound elastography can be used for guidance in partial breast radiotherapy by visualizing the hard scar tissue around the lumpectomy cavity. For clinical success, the elastography method needs to be robust to the sources of decorrelation between ultrasound images, specifically fluid motions inside the cavity, change of the appearance of speckles caused by compression or physiologic motions, and out-of-plane motion of the probe. In this report, we extend our previous work where we proposed 1D Analytic Minimization 1D AM of a cost function to calculate robust elasticity images to 2D AM. We show that 2D AM is much faster than 1D AM, which is critically important in creating real-time elastography. In elasticity reconstruction using an inverse problem framework. We also propose a novel strain addition, 2D AM produces high quality strain images in 2D which can be used for calculation technique using Kalman filters, which generates smooth strain images without blurring the images and removing sharp boundaries. We show using simulation, phantom and clinical trials that the 2D AM generates high quality strain images in real-time. This work is in published in 2 IEEE TMI articles 23 pages total, and in 5 conference proceeding papers each paper 8 to 9 pages, 42 pages total. The papers are well received, resulting in more than 55 citations to date according to Google Scholar.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE