Transgenerational Radiation Epigenetics
Annual rept. 1 Sep 2010-31 Aug 2011
FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA
Pagination or Media Count:
To examine the effect of early exposure to irradiation IR and to look for an epigenetic signature we have irradiated pregnant females at gestation day 15. Of the pups that were born, some were sacrificed at 10 weeks for preliminary epigenetic screening. Others were used as breeders for transgenerational studies and still others have been left to take when they develop lung tumors. We have nearly finished collecting tissue from the 10 week mice as well as unirradiated controls. In addition we are nearly done collecting tissue from the F2 generation. Analysis of the tissue will start soon. We have also been weighing the mice at necropsy and have found that the average weight of the irradiated mice is less than the controls. This is an indication that there is an affect of IR on the mice in utero. We are hopeful we will also find an effect on the epigenome.
- Medicine and Medical Research