Treatment of TBI and Concomitant Hemorrhage with Ghrelin
Annual rept. 1 Jul 2010-30 Jun 2011
FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
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Novel therapeutic advances in the field of trauma management depend upon animal models that can accurately predict the clinical efficacy of interventions. In the battlefield, traumatic brain injury TBI and hemorrhagic shock often occur concomitantly due to multiple injuries. In this project, we determined the long-term effect of ghrelin, a gut-brain hormone, in a highly military relevant experimental rat model of TBI combined with uncontrolled hemorrhagic shock. Our results showed that ghrelin improves long-term brain function, prevents weight loss and decreases mortality after traumatic brain injury and uncontrolled hemorrhagic shock. Thus, ghrelin can be further developed as a safe and effective resuscitation approach for the trauma victim with brain injury and severe blood loss.
- Medicine and Medical Research