Accession Number:

ADA555907

Title:

Treatment of TBI and Concomitant Hemorrhage with Ghrelin

Descriptive Note:

Annual rept. 1 Jul 2010-30 Jun 2011

Corporate Author:

FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY

Personal Author(s):

Report Date:

2011-07-01

Pagination or Media Count:

10.0

Abstract:

Novel therapeutic advances in the field of trauma management depend upon animal models that can accurately predict the clinical efficacy of interventions. In the battlefield, traumatic brain injury TBI and hemorrhagic shock often occur concomitantly due to multiple injuries. In this project, we determined the long-term effect of ghrelin, a gut-brain hormone, in a highly military relevant experimental rat model of TBI combined with uncontrolled hemorrhagic shock. Our results showed that ghrelin improves long-term brain function, prevents weight loss and decreases mortality after traumatic brain injury and uncontrolled hemorrhagic shock. Thus, ghrelin can be further developed as a safe and effective resuscitation approach for the trauma victim with brain injury and severe blood loss.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE