Characterization of IKBKE as a Breast Cancer Oncogene
Annual summary rept. 1 Oct 2008-30 Sep 2011
DANA-FARBER CANCER INST BOSTON MA
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A summary is presented of research performed during three years of a project to further characterize the breast cancer oncogene IKKepsilon. Two specific aims were pursued. The first was to determine the role of ubiquitination in the upstream regulation of IKKepsilon. The second aim created a mammary-specific constitutive IKKepsilon transgenic mouse model to study the role of IKKepsilon in breast cancer initiation and maintenance. The long term goals of this research were to elucidate the mechanism of IKKepsilon upstream regulation in order to better understand how it is dysregulated and overexpressed in human breast cancer and also to create a genetic animal model of IKKepsilon breast cancer initiation for further study.
- Anatomy and Physiology
- Medicine and Medical Research