Medial Prefrontal Cortex and HPA Axis Roles in Generation of PTSD-Like Symptoms in SPS Model
Annual rept. 1 Sep 2010-31 Aug 2011
MICHIGAN UNIV ANN ARBOR
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The research we have conducted over the third year of this research program is contained in this report. We have made substantial progress towards completing all of the proposed research in this program within proposed time frame i.e. final report on 92912. During the last year, we have demonstrated that 1 decreases in neural activity in the BLA and hippocampus are critical for SPS-enhanced fear renewal specific aims 1a and b, 2 have linked SPS-enhanced glucocorticoid receptor expression to SPS-induced extinction recall deficits specific aim 1c, 3 demonstrated that the BLA is critical for social interactions specific aim 2, and 4 demonstrated that SPS induces cognitive deficits, which may be relevant to emotional regulation specific aim 3.
- Anatomy and Physiology
- Medicine and Medical Research