Accession Number:

ADA555892

Title:

Kevlar Vest Protection Against Blast Overpressure Brain Injury: Systemic Contributions to Injury Etiology

Descriptive Note:

Annual rept. 1 May 2010-30 Apr 2011

Corporate Author:

GENEVA FOUNDATION TACOMA WA

Personal Author(s):

Report Date:

2011-05-01

Pagination or Media Count:

12.0

Abstract:

The etiology of blast-induced traumatic brain injury TBI is largely undefined. Along with reducing mortality, in preliminary experiments Kevlar vests significantly protected against BOP-induced neuropathological changes in rats. We postulate that 1 much of the blast-induced fiber degeneration in brain results from pressure surges transmitted through the vasculature that elicit a series of intracranial disruptions, and 2 Kevlar vests are neuroprotective by uncoupling this pressure transmission following exposure to blast. Using a compression driven shock tube, we compare external, systemic e.g. vascular arterial and venous, and central e.g. intracranial pressure BOP-induced pressure changes, and assess the impact of Kevlar vests on these changes. We seek to 1 determine if measured pressure changes are blast severity-dependent and correspond with outcome measures, and 2 assess the impact of Kevlar vests on measured BOP-induced pressure changes and outcome measures and establish whether a protective vest encasing the thorax ameliorates blast-induced brain injury, pointing to a significant contribution of the effects of blast on the thorax to brain injury. These studies will provide critical insights into the etiology of blast-induced brain injury, and will advance the development of mitigation strategies.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE