An fMRI Study of TBI Associated with Blast Injury
Final rept. 15 Feb 2008-28 Feb 2011
NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD
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Using fMRI, we are conducting an observational study to characterize the pattern of brain activation during performance of cognitive control and working memory tasks in service personnel with mild traumatic brain injury TBI and severe TBI imaged between 3 and 42 months after injury. To date, 447 patients with TBI at Walter Reed Army Medical Center WRAMC have been screened. Thirteen patients diagnosed with TBI resulting from blast have met the eligibility criteria and are enrolled in the protocol. Nine patients have completed the neuropsychological testing and four have completed the subsequent MRI series. The National Naval Medical Center NNMC has been added as a research site to address the unexpectedly low rate of eligible patients at WRAMC and consequent slow recruitment into the protocol. NNMC IRB gave final approval of the protocol 13 October 2010. Continuing review reports are in place at WRAMC, NMRC, and NNMC. Continuation was approved by WRAMC on 14 December and NNMC IRB will meet on 10 February for review. Contributions from the present study, specifically the addition of a patient group with severe TBI associated with blast, are expected to complement research findings with this patient population recently released and upcoming in the literature Levin et al., 2010 Brody et al., under review.
- Medicine and Medical Research
- Weapons Effects (Biological)