Purinergic Receptors in Quiescence and Localization of Leukemic Stem Cells
Annual rept. 1 May 2010-30 Apr 2011
PITTSBURGH UNIV PA
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A small subpopulation of drug- and radiation-resistant leukemia is an immediate concern for leukemia patients as this subtype remains the actual cause of morbidity and mortality. Our preliminary results showed that P2Y14 functions in bone marrow to preserve stem progenitor cells from premature senescencecell death induced by genotoxic stress. As P2Y14 is highly expressed in differentiation resistant leukemia cells, P2Y14 expression in leukemia cells may function in preserving regenerative capacity by constraining cell deathsenescence induction. We also found that P2Y14 axis is associated with stem cell mobilization. By providing a mechanistic insight for the roles of P2Y14 in the genotoxic stress-induced injury, directly documenting the effects of P2Y14UDP-Glc axis on stem cell mobilization, our preliminary results are expected to provide the foundation for an effective treatment to destroy therapy resistant leukemia cells.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research