Accession Number:

ADA555796

Title:

Advanced MRI in Acute Military TBI

Descriptive Note:

Annual rept. 1 Sep 2010-31 Aug 2011

Corporate Author:

WASHINGTON UNIV ST LOUIS MO

Personal Author(s):

Report Date:

2011-09-01

Pagination or Media Count:

7.0

Abstract:

The objective of this project is to test two advanced Magnetic Resonance Imaging MRI methods, Diffusion Tensor Imaging DTI and resting-state Functional Magnetic Resonance Imaging fMRI, in military Traumatic Brain Injury TBI patients acutely after injury, and to correlate the findings with TBI-related clinical outcomes 6-12 months later. An additional objective is to test the interaction of candidate genetic vulnerability factors with patterns of injury. These combined methods may add clinically useful predictive information following TBI that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis is that traumatic axonal injury, interacting with genetic vulnerability factors, is a principal cause of impaired brain function following blast-related and non-blast-related TBI. The study is a prospective longitudinal study with subject enrollment and initial evaluation at Landstuhl Regional Medical Center in Landstuhl, Germany. Follow-up evaluations are performed at Washington University in St Louis. To date, 129 subjects have been enrolled and 37 complete follow-up evaluations have been performed. There have been no adverse events

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research
  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE