Dietary and Environmental Exposure to Cadmium and the Risk of Breast Cancer
Annual rept. 15 Sep 2010-14 Sep 2011
CANCER PREVENTION INST OF CALIFORNIA FREMONT
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This proposed study will examine whether exposure to cadmium Cd from dietary or environmental sources increases the risk of breast cancer. We will examine this hypothesis using information collected from the California Teachers Study CTS cohort, a group of approximately 130,000 female school employees living in California followed for breast cancer since 1995. Information collected by questionnaire includes residential addresses, exposure to tobacco smoke, and food and beverage consumption. We will assess levels of dietary and environmental exposure by linking these collected data with available information on Cd residue levels in foods and beverages and environmental sources of Cd pollution near women s residences. In addition, we will estimate total Cd exposure by using existing urine samples provided by 304 women in the CTS to determine the relative contributions of dietary and environmental sources to the level of urinary Cd, which is considered a good measure of cumulative lifetime exposure. We will then evaluate whether dietary, environmental, and total exposure to Cd increase the risk of breast cancer. We made substantial progress in the third year of the study. Using assessed dietary and environmental exposures for the entire CTS cohort, we conducted several analyses to evaluate whether Cd increases the risk of breast cancer. We observed an increased risk for ER- breast cancer associated with residential proximity to high vehicular traffic density and with residence in a census tract with an elevated Cd concentration in ambient air. We are nearing completing our first manuscript on measured urinary Cd concentrations obtained from the sub-study of 304 women. In addition, we are preparing manuscripts on the breast cancer risk analyses.
- Medicine and Medical Research
- Food, Food Service and Nutrition
- Stress Physiology